N-Methyltetrahydrofolic Acid

Basic Information

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CAS Number

134-35-0

Molecular Formula

C20H25N7O6

Molecular Weight

499.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

>300°C (dec.)

SMILES

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CN1C(CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

InChI

InChI=1S/C20H25N7O6.Ca/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29;/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31);/t12?,13-;/m0./s1

InChIKey

BGJXXVMOQCHQBO-ZEDZUCNESA-N

LogP

-0.638499999999999

Topological Polar Surface Area

202.76999999999998 Å²

Hydrogen Bond Donor/Acceptor

8 / 13

Complexity

865

Synonyms & References

English

AKOS030242298
Methyl folate
5-Methyltetrahydrofolate
5-Methyl THF
5-METHYLTETRAHYDROFOLATE [WHO-DD]
N-(5-methyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N(5)-methyl-tetrahydrofolic acid
L-Glutamic acid, N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
SCHEMBL4727836
DB04789
MFCD00900533
5-METHYLTETRAHYDROFOLIC ACID
W-201118
5-Methyl THF5-Methyl THF
5-methyltetrahydropteroylglutamic acid
5-Methyl terahydrofolic acid
A806767
5-methyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
CS-0059429
N5-Methyltetrahydropteroylglutamate
n5-methyltetrahydrofolic acid
Prefolic A
(2S)-2-[[4-[(2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
n-methyltetrahydrofolate
(2S)-2-(4-(((2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
(2S)-2-(4-(((2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioicacid
5-Methyltetrahydropteroylglutamate
5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID
DTXCID9028253
HY-113046
(4-(((2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid

MDL Number

MFCD00900533

FAQ

What is N-Methyltetrahydrofolic Acid (CAS: 134-35-0)?

N-Methyltetrahydrofolic Acid (N-MeTHFA, CAS: 134-35-0) is a form of folic acid, a water-soluble B vitamin that is crucial for DNA synthesis and repair. It has a chemical formula of C19H25FN3O6 and is an important dietary supplement and pharmaceutical ingredient.

What are the main uses of N-Methyltetrahydrofolic Acid (CAS: 134-35-0)?

N-Methyltetrahydrofolic Acid (N-MeTHFA, CAS: 134-35-0) is widely used as a dietary supplement to help prevent neural tube defects in pregnant women. It is also employed in pharmaceutical formulations, food fortification, and as a research reagent in biochemistry and molecular biology.

Is N-Methyltetrahydrofolic Acid (CAS: 134-35-0) safe?

N-Methyltetrahydrofolic Acid (N-MeTHFA, CAS: 134-35-0) is generally considered safe when used as directed. However, it is important to follow recommended dosages and consult a healthcare provider for specific advice, especially for pregnant women. Potential side effects are rare but may include allergic reactions or gastrointestinal issues.

How should N-Methyltetrahydrofolic Acid (CAS: 134-35-0) be stored?

N-Methyltetrahydrofolic Acid (N-MeTHFA, CAS: 134-35-0) should be stored in a cool, dry place away from direct sunlight and moisture. It should be kept in a tightly sealed container to protect it from humidity and light exposure. Avoid storing it in high-temperature areas to maintain its stability and efficacy.