5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine

Basic Information

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CAS Number

1223404-88-3

Molecular Formula

C16H15F2N5

Molecular Weight

315.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Density

1.50±0.1 g/cm3(Predicted)

SMILES

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c1cc(c(cc1F)[C@H]2CCCN2c3ccn4c(n3)c(cn4)N)F

InChI

InChI=1S/C16H15F2N5/c17-10-3-4-12(18)11(8-10)14-2-1-6-22(14)15-5-7-23-16(21-15)13(19)9-20-23/h3-5,7-9,14H,1-2,6,19H2/t14-/m1/s1

InChIKey

PNTNLXBVYHOZQI-CQSZACIVSA-N

LogP

2.9311999999999996

pKa

3.14±0.30(Predicted)

Topological Polar Surface Area

59.45 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

425

Synonyms & References

English

(R)-5-[2-(2,5-difluorophenyl)-1-pyrrolidine] pyrazole and [1,5- a] pyrimidine-3-amine
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine
LOXO101 intermediate
LOXO101 int.
C16H15F2N5
SB18055
5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine

MDL Number

MFCD30802505

FAQ

What regulatory guidelines apply to 5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine (CAS: 1223404-88-3)?

The compound must comply with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS), REACH regulations in the EU, and FDA/EPA guidelines for chemical safety and environmental protection. Specific testing and reporting requirements may also apply based on intended use.

Are there alternatives to 5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine (CAS: 1223404-88-3) in synthesis?

Several alternatives can be used, including related pyrazolo[1,5-a]pyrimidin-3-amine derivatives or other nitrogen-containing heterocycles. Common substitutes include 5-aminopyrazolo[1,5-a]pyrimidines and their analogs with similar functional groups.

What is the market or research trend for 5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine (CAS: 1223404-88-3)?

The compound shows increasing interest in drug discovery and development, particularly for treating neurological and psychiatric disorders due to its structural features. Market trends indicate rising research activity and potential for commercial applications.

How should waste containing 5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-amine (CAS: 1223404-88-3) be handled?

Waste should be collected in appropriate containers and disposed of through professional waste disposal services. Incineration is a common method, but environmental protection measures must be taken to prevent emissions. Chemical neutralization and safe transportation also ensure compliance with environmental regulations.