6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A | CAS No. 121584-52-9

6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A

Basic Information

CAS Number

121584-52-9

Molecular Formula

C62H109N11O14

Molecular Weight

1232.59 g/mol

AD

Basic Physical Properties

O=CC[C@H]([C@H]([C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)OC(=O)C)C

InChI

InChI=1S/C62H109N11O14/c1-25-43-58(82)67(18)32-48(76)68(19)44(28-33(2)3)55(79)66-49(37(10)11)61(85)69(20)45(29-34(4)5)54(78)63-40(15)53(77)64-41(16)57(81)70(21)46(30-35(6)7)59(83)71(22)47(31-36(8)9)60(84)72(23)50(38(12)13)62(86)73(24)51(56(80)65-43)52(87-42(17)75)39(14)26-27-74/h27,33-41,43-47,49-52H,25-26,28-32H2,1-24H3,(H,63,78)(H,64,77)(H,65,80)(H,66,79)/t39-,40+,41-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChIKey

HPSRJUOXPOJSMJ-IBFGMFDFSA-N

LogP

2.4625999999999975

Topological Polar Surface Area

301.94000000000005 Ų

Hydrogen Bond Donor/Acceptor

4 / 25

Synonyms & References

English

  • 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A
  • [(3R,14S)-5-(dimethylamino)-3,15-dimethyl-14-[[(2S)-4-methyl-2-(methylamino)pentanoyl]amino]-1,6,13-trioxohexadecan-4-yl] acetate
  • acetyl-cyclosporin A aldehyde
  • O-acetyl-CsA-aldehyde

MDL Number

MFCD30534406

FAQ

What is 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A (CAS: 121584-52-9)?

Cyclosporin A (CAS: 121584-52-9) is a macrolide immunosuppressive drug with a complex chemical structure. It consists of a 11-membered lactone ring and a norleucine residue. This compound is known for its selective inhibition of T-lymphocyte activation, making it a crucial medication in organ transplantation and autoimmune diseases.

What are the main uses of 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A (CAS: 121584-52-9)?

Cyclosporin A (CAS: 121584-52-9) is primarily used to prevent organ rejection in transplant patients and to treat autoimmune diseases such as psoriasis and rheumatoid arthritis. It is also used in the management of other immune-related conditions.

Is 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A (CAS: 121584-52-9) safe?

Cyclosporin A (CAS: 121584-52-9) can be safe when used under medical supervision. However, it requires close monitoring due to potential side effects, including nephrotoxicity, hypertension, and infections. Adherence to prescribed dosages and regular check-ups are essential for safe use.

How should 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine] Cyclosporin A (CAS: 121584-52-9) be stored?

Cyclosporin A (CAS: 121584-52-9) should be stored at controlled room temperature (15-30°C) away from direct sunlight and sources of heat. It should be protected from moisture and stored in a tightly sealed container to maintain its stability and potency.

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