Nelarabine | CAS No. 121032-29-9

Nelarabine

Basic Information

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CAS Number

121032-29-9

Molecular Formula

C11H15N5O5

Molecular Weight

297.27 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

212°C

Boiling Point

721°C at 760 mmHg

Specific Rotation

+55.9° (c=0.27, DMF)

SMILES

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COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N

InChI

InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1

InChIKey

IXOXBSCIXZEQEQ-UHTZMRCNSA-N

LogP

-1.9713999999999994

Topological Polar Surface Area

148.77 Å²

Hydrogen Bond Donor/Acceptor

5 / 10

Complexity

377

Safety Information

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GHS Hazard Pictograms

H361

Hazard Statement

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Synonyms & References

English

DTXSID6046842
NCGC00181098-01
9-beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
D05134
2-Amino-6-methoxy-9-b-D-arabinofuranosyl-9H-purine
NSC-686673
9-.BETA.-D-ARABINOFURANOSYL-6-METHOXY-9H-PURIN-2-AMINE
9H-Purin-2-amine, 9beta-D-arabinofuranosyl-6-methyl-
SR-01000931847
CHEMBL1201112
GTPL7090
MFCD00871078
NELARABINE [ORANGE BOOK]
CHEBI:63612
(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
BDBM50247985
IXOXBSCIXZEQEQ-UHTZMRCNSA-N
UNII-60158CV180
NELARABINE [MART.]
S1213
Nelarabine [USAN]
DTXCID4026842
Arranon
BCP9000318
HMS3715I16
NELARABINE [VANDF]
AB01274773_02
SMR002544682
GW506U78
NSC755985
GW 506U78

MDL Number

MFCD00871078

FAQ

What is Nelarabine (CAS: 121032-29-9)?

Nelarabine is a chemotherapy drug primarily used in the treatment of certain types of leukemia. Its chemical name is 2-amino-2-deoxy-1-beta-D-ribofuranosyl-1,3-dihydro-4H-pyrazol-4-one. It is a white to off-white crystalline solid with a molecular weight of 265.26 g/mol and is soluble in water and some organic solvents.

What are the main uses of Nelarabine (CAS: 121032-29-9)?

Nelarabine is mainly used in oncology for treating T-cell lymphoblastic leukemia and lymphoma. It functions as a nucleoside analog, inhibiting DNA synthesis in cancer cells. It is also used in research for studying DNA repair mechanisms and as a tool in pharmaceutical development for antiviral and anticancer compounds.

Is Nelarabine (CAS: 121032-29-9) safe?

Nelarabine is generally safe when used under medical supervision, but it can cause side effects such as bone marrow suppression and gastrointestinal issues. Proper handling and adherence to safety guidelines are essential. It is classified as a pharmaceutical compound with specific safety standards in place for its use in clinical settings.

How should Nelarabine (CAS: 121032-29-9) be stored?

Nelarabine should be stored in a cool, dry place away from light. It is typically kept in airtight containers at a temperature between 15°C to 25°C. Proper storage ensures stability and prevents degradation, maintaining its efficacy for pharmaceutical use.