Ampicillin EP Impurity E

Basic Information

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CAS Number

1207726-28-0

Molecular Formula

C24H26N4O5S

Molecular Weight

482.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

847.4±65.0 °C at 760 mmHg

Density

1.4±0.1 g/cm3

Flash Point

466.3±34.3 °C

Vapor Pressure

0.0±3.3 mmHg at 25°C

SMILES

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CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](c3ccccc3)N)C(=O)N[C@H](c4ccccc4)C(=O)O)C

InChI

InChI=1S/C24H26N4O5S/c1-24(2)18(20(30)26-16(23(32)33)14-11-7-4-8-12-14)28-21(31)17(22(28)34-24)27-19(29)15(25)13-9-5-3-6-10-13/h3-12,15-18,22H,25H2,1-2H3,(H,26,30)(H,27,29)(H,32,33)/t15-,16-,17-,18+,22-/m1/s1

InChIKey

VSAAMYOCWYQYDF-OSAVLUCMSA-N

LogP

1.1756

Topological Polar Surface Area

141.82999999999998 Å²

Hydrogen Bond Donor/Acceptor

5 / 9

Complexity

824

Synonyms & References

English

Ampicillinyl-D-phenylglycine
Ampicillin EP Impurity E
7811RA358Y
(R)-2-((2S,5R,6R)-6-((R)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxamido)-2-phenylacetic acid
Ampicillin phenylglycylamide
Q27266625

FAQ

What are the physical and chemical properties of Ampicillin EP Impurity E (CAS: 1207726-28-0)?

Ampicillin EP Impurity E (CAS: 1207726-28-0) is a white to off-white crystalline powder. It has a molecular weight of approximately 465.54 g/mol. The compound is slightly soluble in water and practically insoluble in ethanol. Chemically, it is a derivative of ampicillin, and exhibits similar reactivity with common nucleophiles and bases. It shows weak to moderate acidity and can undergo hydrolysis under acidic conditions.

How is Ampicillin EP Impurity E (CAS: 1207726-28-0) typically synthesized?

Ampicillin EP Impurity E (CAS: 1207726-28-0) is synthesized through the hydrolysis of ampicillin. This involves treating ampicillin with an aqueous base, such as sodium hydroxide, to produce the desired impurity. The reaction is selective and yields high purity of the impurity, which is then purified by techniques such as recrystallization or chromatography.

What industries use Ampicillin EP Impurity E (CAS: 1207726-28-0)?

Ampicillin EP Impurity E (CAS: 1207726-28-0) is primarily used in the pharmaceutical industry, particularly in the production of ampicillin and related antibiotics. It may also have applications in the research of antibiotic resistance mechanisms and in quality control checks for ampicillin and other beta-lactam antibiotics.

What precautions should be taken when handling Ampicillin EP Impurity E (CAS: 1207726-28-0)?

When handling Ampicillin EP Impurity E (CAS: 1207726-28-0), it is important to use personal protective equipment such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using caution, and the appropriate safety data sheet (SDS) should be referenced for specific handling instructions. Proper disposal procedures should be followed to ensure environmental safety.