(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid

Basic Information

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CAS Number

120205-50-7

Molecular Formula

C14H25NO5

Molecular Weight

287.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

397.8±17.0°C at 760 mmHg

SMILES

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CC(C(C1CCCN1C(=O)OC(C)(C)C)OC)C(=O)O

InChI

InChI=1S/C14H25NO5/c1-9(12(16)17)11(19-5)10-7-6-8-15(10)13(18)20-14(2,3)4/h9-11H,6-8H2,1-5H3,(H,16,17)/t9-,10+,11-/m1/s1

InChIKey

LNEHHTWYEBGHBY-OUAUKWLOSA-N

LogP

2.1216

Topological Polar Surface Area

76.07 Å²

Hydrogen Bond Donor/Acceptor

1 / 6

Complexity

363

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(2R,3R)-3-((S)-1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
(2R,3R)-BOC-dolaproine
((2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-Methoxy-2-Methylpropanoic acid
Boc-Dap
DOLPROLINE
N-Boc-dolaproline
N-Boc-dolaproline acid
(2R,3R)-3-methoxy-2-methyl-3-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]propanoic acid
N-Boc-dolaproine
EOS-60617
Dolastatin 10 intermediate Dap
N-Boc-Dolaproline (K salt) (N-Boc-DAP-K salt) (free acid)
(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-Methoxy-2-Methylpropanoic acid (DAP)
(2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
AK126815
LNEHHTWYEBGHBY-OUAUKWLOSA-N
RL00796
OR3
AMY30680
VEA20550
(2R,3R)-3-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoic acid
((2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
CS-B0750
(2R,3R)-3-((S)-1-(t-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanic acid
BOC-DAP
BP-20231
HY-33046
SCHEMBL903564
DS-5307
(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
MFCD18157735

MDL Number

MFCD18157735

FAQ

What regulatory guidelines apply to (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid (CAS: 120205-50-7)?

The compound (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid (CAS: 120205-50-7) should comply with GHS classification, REACH regulations, and FDA/EPA requirements. It is classified as a non-hazardous substance under GHS, but specific handling guidelines and storage conditions must be followed to ensure safety and compliance. REACH regulations require registration, evaluation, and authorization for certain uses. FDA and EPA guidelines are necessary for ensuring safe use in pharmaceuticals and environmental safety respectively.

Are there alternatives to (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid in synthesis (CAS: 120205-50-7)?

Several alternatives can be used in the synthesis of (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid (CAS: 120205-50-7). For example, (2R,3R)-3-hydroxy-3-methoxy-2-methylpropanoic acid and (2R,3R)-3-(aminomethyl)-3-methoxy-2-methylpropanoic acid are common analogs. Other alternatives include the use of different protecting groups or substituents. However, the choice depends on the specific requirements of the synthesis and the desired properties of the final product.

What is the market or research trend for (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid (CAS: 120205-50-7)?

There is increasing interest in (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid (CAS: 120205-50-7) due to its potential applications in drug discovery and medicinal chemistry. Research trends are focusing on its use as a precursor in the synthesis of complex molecules and as a pharmacological agent. Market demand is driven by advancements in biotechnology and personalized medicine, with a growing emphasis on developing innovative chemical entities for therapeutic use.

How should waste containing (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid (CAS: 120205-50-7) be handled?

Waste containing (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid (CAS: 120205-50-7) should be collected in appropriate containers and disposed of through professional waste disposal services. Incineration is a common method for disposal, as it ensures complete destruction of the compound. Environmental protection precautions include proper labeling, handling, and transportation to minimize environmental impact. Compliance with local regulations is essential for safe and environmentally responsible disposal.