4-(Aminomethyl)-2-methoxyphenol

Basic Information

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CAS Number

1196-92-5

Molecular Formula

C8H11NO2

Molecular Weight

153.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

145-146 ºC

Boiling Point

292.9±25.0 ºC (760 Torr),

Flash Point

130.9±23.2 ºC,

SMILES

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COC1=C(C=CC(=C1)CN)O

InChI

InChI=1S/C8H11NO2/c1-11-8-4-6(5-9)2-3-7(8)10/h2-4,10H,5,9H2,1H3

InChIKey

WRPWWVNUCXQDQV-UHFFFAOYSA-N

LogP

0.8594999999999999

Topological Polar Surface Area

55.480000000000004 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

119

Safety Information

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GHS Hazard Pictograms

H319

Hazard Statement

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

SY236723
a-amino-2-methoxy-p-Cresol
HY-W097899
EN300-57329
A15041
CHEBI:46958
1196-92-5
EN300-36042
4-(Aminomethyl)-2-methoxyphenol #
DTXSID90152522
4-(Aminomethyl)-2-methoxyphenol, AldrichCPR
1WEZ91E3Z0
CS-0150541
vanillylamin
4-hydroxy-3-methoxy-benzylamine
BS-19988
((4-HYDROXY-3-METHOXYPHENYL)METHYL)AMINE
4-Hydroxy-3-methoxybenzylamine
CREOSOL, .ALPHA.-AMINO-
UNII-1WEZ91E3Z0
3-Methoxy-4-hydroxybenzylamine
p-Cresol, .alpha.-amino-2-methoxy-
AKOS000126460
(4-Hydroxy-3-methoxyphenyl)methanamine
CAPSIVIROL-T
4-(aminomethyl)-2-(methyloxy)phenol
alpha-amino-2-methoxy-p-Cresol
BDBM626157
4-(Aminomethyl)-2-methoxyphenol
D94459
Q17105361

MDL Number

MFCD00044577

FAQ

What are the physical and chemical properties of 4-(Aminomethyl)-2-methoxyphenol (CAS: 1196-92-5)?

4-(Aminomethyl)-2-methoxyphenol (CAS: 1196-92-5) is a white to off-white crystalline solid. Its molecular weight is approximately 184.24 g/mol. This compound is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. It is known for its basicity due to the aminomethyl group and can react with acidic compounds to form salts. It is stable under normal storage conditions but should be kept away from strong acids and oxidizers.

How is 4-(Aminomethyl)-2-methoxyphenol (CAS: 1196-92-5) typically synthesized?

4-(Aminomethyl)-2-methoxyphenol (CAS: 1196-92-5) is typically synthesized via the reaction of 2-methoxyacetophenone with ammonia or an ammonia solution in the presence of a suitable catalyst. The method involves the nucleophilic addition of ammonia to the carbonyl group of 2-methoxyacetophenone, followed by reduction of the resulting amide to the aminomethyl group. The yield is usually around 70-80% depending on the reaction conditions.

What industries use 4-(Aminomethyl)-2-methoxyphenol (CAS: 1196-92-5)?

4-(Aminomethyl)-2-methoxyphenol (CAS: 1196-92-5) finds applications in various industries including pharmaceuticals, where it serves as a precursor for the synthesis of certain drugs. It is also used in the production of dyes and pigments, as a stabilizer in polymer formulations, and in the development of chemical sensors for detecting specific analytes due to its functional groups.

What precautions should be taken when handling 4-(Aminomethyl)-2-methoxyphenol (CAS: 1196-92-5)?

When handling 4-(Aminomethyl)-2-methoxyphenol (CAS: 1196-92-5), it is important to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up with care using suitable absorbents, and disposal should follow local regulations. A Material Safety Data Sheet (MSDS) should always be consulted for detailed safety information.