N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate (1:1)

Basic Information

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CAS Number

1195768-06-9

Molecular Formula

C24H24F3N5O5S3

Molecular Weight

615.68 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)(C)c1nc(c(s1)c2ccnc(n2)N)c3cccc(c3F)NS(=O)(=O)c4c(cccc4F)F.CS(=O)(=O)O

InChI

InChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)

InChIKey

YKGMKSIHIVVYKY-UHFFFAOYSA-N

LogP

4.868900000000003

Topological Polar Surface Area

165.22999999999996 Å²

Hydrogen Bond Donor/Acceptor

4 / 10

Complexity

910

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Dabrafenib Mesylate(GSK-2118436B)
Dabrafenib Mesylate
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide,methanesulfonic acid
GSK 2118436B
GSK2118436 Mesylate
GSK-2118436 Mesylate
UNII-B6DC89I63E
GSK 2118436 methanesulfonate salt
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide methanesulfonate
Dabrafenib (Mesylate)
METHANE SULFONATE SALT
Dabrafenib mesylate [USAN]
B6DC89I63E
GSK2118436B
Dabrafenib mesylate (USAN)
Taflinar
N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide methanesulfonate
Dabrafenib methanesulfonate
Tafinlar (TN)
GSK2118436 Methane sulfonate salt

MDL Number

MFCD20922872

FAQ

What is N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate (CAS: 1195768-06-9)?

N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate is a complex organic compound with a CAS number of 1195768-06-9. It is a derivative of benzene and pyrimidine, with properties such as chemical stability and solubility in organic solvents. This compound is often used in pharmaceutical research and development.

What are the main uses of N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate (CAS: 1195768-06-9)?

N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate is primarily used in pharmaceutical research for developing new drugs and compounds. It may also have applications in chemical synthesis and materials science.

Is N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate (CAS: 1195768-06-9) safe?

N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate is generally safe when handled properly. Users should follow safety guidelines, including wearing appropriate personal protective equipment (PPE) and storing it in a secure, well-ventilated area. Avoid contact with skin and eyes, and dispose of waste materials according to local regulations.

How should N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate (CAS: 1195768-06-9) be stored?

N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(2-methyl-2-propanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide methanesulfonate should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container, preferably a glass or plastic container with a tight-fitting lid. Store at room temperature (15-30°C), and avoid prolonged exposure to humidity and moisture.