![(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate structure](https://static.chemtradehub.com/structs/102/1022150-11-3-96ed.webp "(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate structure")
(R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
CAS Number:
1022150-11-3
Molecular Formula:
C27H30N6O3
2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid | CAS No. 1152782-19-8
2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
Basic Information
CAS Number
1152782-19-8
Molecular Formula
C20H19F3N2O3
Molecular Weight
392.38 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 2-[({4-[2-(Trifluoromethyl)phenyl]-1-piperidinyl}carbonyl)amino]b enzoic acid
- A 1120
- NS00072593
- A1120?
- BRD-K59060513-001-01-7
- SCHEMBL1230989
- 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid
- A1120
- DA-60639
- 2-{4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonylamino}benzoic acid
- NCGC00370977-01
- 1152782-19-8
- 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
- BS-52649
- A1120, >=98% (HPLC), powder
- GTPL8792
- compound 33 [PMID: 24835984]
- CHEMBL1230001
- HY-107633
- HMS3743G05
- 2-[[4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl]amino]benzoic acid
- BDBM50019040
- A-1120
- 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido) benzoic acid
- D81163
- Q27074049
- DB06985
- CS-0029033
- AKOS024457802
- CWB78219
- 2T1
MDL Number
MFCD12912393
FAQ
What are the physical and chemical properties of 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid (CAS: 1152782-19-8)?
2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid is a crystalline solid with a molecular weight of approximately 497.35 g/mol. It has a low solubility in water (0.01 g/100 mL at 25°C) and moderate solubility in organic solvents such as methanol and dimethylformamide. This compound is reactive towards hydrolysis and can undergo esterification and amide formation under appropriate conditions. It is stable under normal storage conditions but should be protected from moisture and light.
How is 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid (CAS: 1152782-19-8) typically synthesized?
2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid is typically synthesized via the condensation of 2-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxylic acid and benzoyl chloride in the presence of a catalytic amount of a tertiary amine such as N,N'-dimethylaminopyridine. The reaction is carried out in a suitable organic solvent like dichloromethane or toluene, and the product is isolated via recrystallization from a suitable solvent. The yield is generally around 70-80%, and the method is selective and practical for preparative purposes.
What industries use 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid (CAS: 1152782-19-8)?
2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug candidates. It has also found applications in the polymer industry as a functional monomer, and in the sensor industry for the development of gas sensors. Its unique chemical structure makes it a valuable compound in research and development for its potential in various fields.
What precautions should be taken when handling 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid (CAS: 1152782-19-8)?
When handling 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid, appropriate personal protective equipment (PPE) should be worn, including safety goggles, gloves, and a lab coat. The compound should be stored in a cool, dry place, away from direct sunlight. Fume hoods should be used when performing operations that may release vapors. In case of a spill, the area should be immediately flushed with water, and the spill should be cleaned up using an appropriate absorbent material. Always refer to the Material Safety Data Sheet (MSDS) for specific safety and handling guidelines.
Related Compounds
![[(3aS,5R,6S,6aS)-6-Hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl](4-morpholinyl)methanone (non-preferred name) structure](https://static.chemtradehub.com/structs/110/1103738-19-7-ae24.webp "[(3aS,5R,6S,6aS)-6-Hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl](4-morpholinyl)methanone (non-preferred name) structure")
[(3aS,5R,6S,6aS)-6-Hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl](4-morpholinyl)methanone (non-preferred name)
CAS Number:
1103738-19-7
Molecular Formula:
C12H19NO6
MYO-INOSITOL HEXAKIS(DIHYDROGEN PHOSPHATE), DODECASODIUM SALT HYDRATE
CAS Number:
123408-98-0
Molecular Formula:
C6H8Na12O25P6
2-Methyl-2-propanyl (3S)-3-cyano-1-pyrrolidinecarboxylate
CAS Number:
132945-78-9
Molecular Formula:
C10H16N2O2
![(5R)-5-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3,4-dihydroxy-2(5H)-furanone structure](https://static.chemtradehub.com/structs/150/15042-01-0-ee1c.webp "(5R)-5-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3,4-dihydroxy-2(5H)-furanone structure")
(5R)-5-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-3,4-dihydroxy-2(5H)-furanone
CAS Number:
15042-01-0
Molecular Formula:
C9H12O6
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