3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite | CAS No. 110894-23-0

3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite

Basic Information

CAS Number

110894-23-0

Molecular Formula

C33H43N2O5P

Molecular Weight

17.03 g/mol

AD

Basic Physical Properties

N#CCCOP(OCCCOC(c1ccc(OC)cc1)(c2ccccc2)c3ccc(OC)cc3)N(C(C)C)C(C)C

InChI

InChI=1S/C33H43N2O5P/c1-26(2)35(27(3)4)41(39-24-10-22-34)40-25-11-23-38-33(28-12-8-7-9-13-28,29-14-18-31(36-5)19-15-29)30-16-20-32(37-6)21-17-30/h7-9,12-21,26-27H,10-11,23-25H2,1-6H3

InChIKey

IMRNWKAKFIGPOS-UHFFFAOYSA-N

LogP

0.16199999999999998

Topological Polar Surface Area

35.0 Ų

Hydrogen Bond Donor/Acceptor

3 / 1

Synonyms & References

English

  • 3-(4,4'-DIMETHOXYTRITYL)PROPANDIOL-1-N,N-DIISOPROPYL (BETA-CYANOETHYL) PHOSPHORAMIDITE
  • 3-(4,4'-DIMETHOXYTRITYL)PROPANDIOL-1-N,N-DIISOPROPYL (β-CYANOETHYL) PHOSPHORAMIDITE
  • SPACER-C3 CEP
  • PROPYL LINKER,C3 SPACER
  • SPACER-C 3 CEP
  • PROPYL LINKER, C3 SPACER

MDL Number

MFCD06804591

FAQ

What are the physical and chemical properties of 3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite (CAS: 110894-23-0)?

3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite (CAS: 110894-23-0) is a colorless or pale yellow oil. It has a molecular weight of approximately 709.5 g/mol and is soluble in organic solvents like DMSO and THF. This compound is highly reactive and can undergo substitution reactions under appropriate conditions.

How is 3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite (CAS: 110894-23-0) typically synthesized?

3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite (CAS: 110894-23-0) is typically synthesized via a multi-step process including protection of the phosphoramidoite group, introduction of the bis(4-methoxyphenyl)(phenyl)methoxy group, and subsequent deprotection. The synthesis involves the use of reagents like tert-butyldimethylsilyl chloride and trifluoroacetic acid, with yields typically ranging from 60-80%.

What industries use 3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite (CAS: 110894-23-0)?

3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite (CAS: 110894-23-0) is used in the pharmaceutical industry for the synthesis of complex organic molecules and in the polymer industry for the modification of polymers to enhance their functionality.

What precautions should be taken when handling 3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite (CAS: 110894-23-0)?

Proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn when handling 3-[Bis(4-methoxyphenyl)(phenyl)methoxy]propyl 2-cyanoethyl diisopropylphosphoramidoite (CAS: 110894-23-0). Ensure all reactions are conducted in a well-ventilated fume hood. In case of a spill, neutralize the spill with an appropriate neutralizing agent and clean up using absorbent materials. Refer to the material safety data sheet (MSDS) for additional safety information.

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