6-(Trifluoromethyl)-3-pyridinamine

Basic Information

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CAS Number

106877-33-2

Molecular Formula

C6H5F3N2

Molecular Weight

162.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

42.0 to 46.0 deg-C

Boiling Point

92-94℃/0.01mmHg

Water Solubility

Slightly soluble in water.

SMILES

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C1=CC(=NC=C1N)C(F)(F)F

InChI

InChI=1S/C6H5F3N2/c7-6(8,9)5-2-1-4(10)3-11-5/h1-3H,10H2

InChIKey

IBOZOWZSXZNIHI-UHFFFAOYSA-N

LogP

1.6826

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

134

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

AM20070179
3-amino-6-trifluoromethyl-pyridine
6-trifluoromethyl-pyridin-3-ylamine
2-TRIFLUOROMETHYL-5-AMINOPYRIDINE
5-Amino-2-trifluoromethylpyridine
6-(trifluoromethyl)pyridin-3-amine
5-amino-2-trifloromethylpyridine
4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBONYLCHLORIDE
6-Trifluoromethyl-3-aminopyridine
Z1203161729
5-Amino-2-(trifluoromethyl)pyridine
3-amino-6-trifluoromethylpyridine
5-amino-2trifluoromethylpyridine
BCP05913
6-(trifluoromethyl)pyridine-3-amine
A801525
SCHEMBL114542
CS-D0794
3-Pyridinamine, 6-(trifluoromethyl)-
AKOS005063463
W-204618
6-Trifluoromethylpyridin-3-ylamine
FT-0619968
EN300-100883
3-amino-6-trifluoromethyl pyridine
5-amino-2-(trifluoromethyl)-pyridine
FS-1198
5-Amino-2-(trifluoromethyl)pyridine, 96%
3-amino-6-(trifluoromethyl)pyridine
6-(trifluoromethyl)-3-pyridinamine
MFCD01862656

MDL Number

MFCD01862656

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 6-(Trifluoromethyl)-3-pyridinamine (CAS: 106877-33-2)?

6-(Trifluoromethyl)-3-pyridinamine is a crystalline solid with a molecular weight of approximately 216.12 g/mol. It is slightly soluble in water and organic solvents. It reacts readily with bases and can form salts. This compound is known for its high reactivity towards nucleophiles and electrophiles.

How is 6-(Trifluoromethyl)-3-pyridinamine (CAS: 106877-33-2) typically synthesized?

6-(Trifluoromethyl)-3-pyridinamine is commonly synthesized through the reduction of 6-(trifluoromethyl)-3-pyridone with sodium borohydride in an aqueous solution. The reaction typically yields a mixture of isomers, with the desired product being isolated by column chromatography or recrystallization.

What industries use 6-(Trifluoromethyl)-3-pyridinamine (CAS: 106877-33-2)?

6-(Trifluoromethyl)-3-pyridinamine is utilized in the pharmaceutical industry for the synthesis of drugs, particularly in the development of anti-inflammatory and analgesic agents. It is also used in the polymer industry for the synthesis of functional monomers and in the semiconductor industry for the fabrication of organic electronic devices.

What precautions should be taken when handling 6-(Trifluoromethyl)-3-pyridinamine (CAS: 106877-33-2)?

When handling 6-(Trifluoromethyl)-3-pyridinamine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or fume hood to minimize inhalation risk. In case of a spill, immediately clean up using appropriate absorbent materials and consult the safety data sheet (SDS) for further instructions.