2-Chloropyrido[2,3-d]pyrimidine

Basic Information

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CAS Number

1060816-71-8

Molecular Formula

C7H4ClN3

Molecular Weight

165.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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Clc1ncc2cccnc2n1

InChI

InChI=1S/C7H4ClN3/c8-7-10-4-5-2-1-3-9-6(5)11-7/h1-4H

InChIKey

HDIKBNMPLHFNKZ-UHFFFAOYSA-N

LogP

1.6781999999999995

Topological Polar Surface Area

38.67 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Synonyms & References

English

2-Chloropyrido[2,3-d]pyrimidine
2-Chloro-pyrido[2,3-d]pyrimidine
AGN-PC-0CWHZ8
AK-78555
ANW-66264
CTK8C1327
FT-0694499
KB-230245
PB31117
2-chloropyrido[2,3-d]pyrimidine

MDL Number

MFCD13189443

FAQ

What are the physical and chemical properties of 2-Chloropyrido[2,3-d]pyrimidine (CAS: 1060816-71-8)?

2-Chloropyrido[2,3-d]pyrimidine is a crystalline solid with a molecular weight of approximately 205.57 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. Chemically, it is relatively stable but can react with strong bases to form pyrimidine derivatives. It is often used in pharmaceutical and chemical research.

How is 2-Chloropyrido[2,3-d]pyrimidine (CAS: 1060816-71-8) typically synthesized?

2-Chloropyrido[2,3-d]pyrimidine is typically synthesized through a multistep process involving the condensation of 2-chloropyridine with 2-bromopyrimidine. The reaction is catalyzed by palladium and is carried out in the presence of a base. The yield is around 70-80%, and selectivity is good, making it a viable method for commercial production.

What industries use 2-Chloropyrido[2,3-d]pyrimidine (CAS: 1060816-71-8)?

2-Chloropyrido[2,3-d]pyrimidine is used primarily in the pharmaceutical industry for the synthesis of various bioactive compounds. It also finds applications in the polymer and semiconductor industries due to its unique electronic properties. Additionally, it is used in the field of chemical research and development.

What precautions should be taken when handling 2-Chloropyrido[2,3-d]pyrimidine (CAS: 1060816-71-8)?

When handling 2-chloropyrido[2,3-d]pyrimidine, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the work is conducted in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, immediately clean it up using appropriate absorbent materials and follow the manufacturer's safety data sheet (SDS) for disposal instructions.