(R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid

Basic Information

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CAS Number

1018899-99-4

Molecular Formula

C22H25NO4

Molecular Weight

367.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

572.1±33.0°C at 760 mmHg

SMILES

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CC(C[C@@H](C(=O)O)CNC(=O)OCC1c2ccccc2c2c1cccc2)C

InChI

InChI=1S/C22H25NO4/c1-14(2)11-15(21(24)25)12-23-22(26)27-13-20-18-9-5-3-7-16(18)17-8-4-6-10-19(17)20/h3-10,14-15,20H,11-13H2,1-2H3,(H,23,26)(H,24,25)/t15-/m1/s1

InChIKey

ONRQUNUKPSDFFF-OAHLLOKOSA-N

LogP

4.272000000000004

Topological Polar Surface Area

75.63000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid
Fmoc-(R)-2-(aminomethyl)-4-methylpentanoic acid
(2R)-2-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]-4-methylpentanoic acid
(R)-Fmoc-beta2-homoleucine
(R)-FMoc-2-aMinoMethyl-4-Methyl-pentanoic acid
(9H-Fluoren-9-yl)MethOxy]Carbonyl (R)-2-(Aminomethyl)-4-methylpentanoic acid
(R)-Fmoc-β2-homoleucine

MDL Number

MFCD07372889

Customs Code

2924299090

FAQ

What are the physical and chemical properties of (R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid (CAS: 1018899-99-4)?

(R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid is a white to off-white crystalline solid with a molecular weight of approximately 434.44 g/mol. It has a high solubility in organic solvents like DMSO and ethanol, but is less soluble in water. The compound exhibits moderate reactivity, particularly under basic conditions. It is stable under normal temperature and pressure conditions but should be stored in a desiccator to prevent moisture absorption.

How is (R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid (CAS: 1018899-99-4) typically synthesized?

(R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid can be synthesized through the condensation of 4-methylpentanoic acid with 9H-fluoren-9-ylmethoxy carbonyl chloride in the presence of a suitable base such as diisopropylethylamine. The reaction is typically carried out in anhydrous organic solvents like dichloromethane or N,N-dimethylformamide. The yield is generally around 70-80%, and the product can be purified by column chromatography or crystallization.

What industries use (R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid (CAS: 1018899-99-4)?

(R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid is primarily used in the pharmaceutical industry for the synthesis of complex molecules and in the polymer industry for the development of novel materials with specific properties. It is also utilized in the production of sensors and semiconductors for its unique functional groups and chemical stability.

What precautions should be taken when handling (R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid (CAS: 1018899-99-4)?

When handling (R)-2-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)-4-methylpentanoic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to laboratory waste regulations. A safety data sheet (SDS) should be consulted for detailed handling and disposal information.