Compound Q&A

How is N-(2-Chlorophenyl)-6-(4-piperidinyl)imidazo[1,2-a]pyridine-3-carboxamide ethanedioate (CAS: 342595-05-5) typically synthesized?

Answer

N-(2-Chlorophenyl)-6-(4-piperidinyl)imidazo[1,2-a]pyridine-3-carboxamide ethanedioate (1:1)
N-(2-Chlorophenyl)-6-(4-piperidinyl)imidazo[1,2-a]pyridine-3-carboxamide ethanedioate is usually synthesized through a multi-step process involving the condensation of an intermediate imidazole derivative with 2-chloro-phenyl piperidine, followed by the formation of the ethanedioate ester. Key reagents include piperidine, chlorophenyl derivatives, and ethanedioic acid. The reaction is typically carried out under mild conditions, with good selectivity and moderate to high yield.

About

English Name N-(2-Chlorophenyl)-6-(4-piperidinyl)imidazo[1,2-a]pyridine-3-carboxamide ethanedioate (1:1)
Molecular Formula C21H21ClN4O5
Molecular Weight 444.88 g/mol
SMILES c1ccc(c(c1)NC(=O)c2cnc3n2cc(cc3)C4CCNCC4)Cl.C(=O)(C(=O)O)O
InChIKey ODBJGLKPAQMCJA-UHFFFAOYSA-N
Last Updated: 2026-04-02 05:05

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