How is Benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate (CAS: 1052715-76-0) typically synthesized?

Benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate is synthesized via a multi-step process involving the amino protection of a piperidine ring, followed by esterification. Common synthetic approaches include the use of tert-butyloxycarbonyl (Boc) protection and benzyl ester formation. The reaction typically requires a suitable solvent like dichloromethane and is catalyzed by a Lewis acid or anhydride. The yield of this synthesis is generally around 70-80%.