Benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate(CAS: 1052715-76-0)

Benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate is a white crystalline solid. Its molecular weight is approximately 407.5 g/mol. The compound is slightly soluble in water but more soluble in organic solvents like methanol and acetone. It is reactive towards nucleophiles and bases, making it suitable for chemical modifications in synthetic reactions.

Benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate is synthesized via a multi-step process involving the amino protection of a piperidine ring, followed by esterification. Common synthetic approaches include the use of tert-butyloxycarbonyl (Boc) protection and benzyl ester formation. The reaction typically requires a suitable solvent like dichloromethane and is catalyzed by a Lewis acid or anhydride. The yield of this synthesis is generally around 70-80%.

Benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate is primarily used in pharmaceuticals and organic synthesis. It serves as a building block for the synthesis of various complex molecules, including drugs. This compound is also utilized in polymer chemistry for the modification of polymers, and in sensor technology for the development of specific chemical sensors.

When handling Benzyl (3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate, it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled by absorbent material and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.