How is N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-6-methyl-2-pyrazinecarboxamide (CAS: 66375-96-0) typically synthesized?

N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-6-methyl-2-pyrazinecarboxamide is synthesized through multistep organic reactions, typically involving the coupling of cyclohexylcarbamoyl sulfamide with 2-(4-aminophenyl)ethyl 6-methyl-2-pyrazinecarboxylate. The reaction is often carried out in the presence of a suitable catalyst and requires high purity starting materials to achieve good yield and selectivity.