Compound Q&A

How is 2-Chloro-2,2-difluoroacetamide (CAS: 354-28-9) typically synthesized?

Answer

2-Chloro-2,2-difluoroacetamide
2-Chloro-2,2-difluoroacetamide is typically synthesized by the addition of hydrogen chloride to 2,2-difluoroacetaldehyde followed by hydrolysis. This process involves the use of a phase transfer catalyst and requires precise control of reaction conditions to achieve high yield and selectivity. The reaction is exothermic, and appropriate cooling may be necessary to prevent side reactions.

About

CAS No 354-28-9
English Name 2-Chloro-2,2-difluoroacetamide
Molecular Formula C2H2ClF2NO
Molecular Weight 129.493 g/mol
SMILES C(=O)(C(F)(F)Cl)N
InChIKey PSAKKOKLSDIKEK-UHFFFAOYSA-N
Last Updated: 2026-03-10 23:59

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