Compound Q&A
How is 5-Chloro-2-(trifluoromethyl)nicotinic acid (CAS: 823222-02-2) typically synthesized?
Answer
5-Chloro-2-(trifluoromethyl)nicotinic acid is typically synthesized via acylation of 2-chloronicotinic acid with trifluoromethyl chloride. This process often involves the use of a Lewis acid catalyst and is carried out under anhydrous conditions to prevent side reactions. The yield is generally good, and the product can be purified by recrystallization.
About
CAS No
823222-02-2
English Name
5-Chloro-2-(trifluoromethyl)nicotinic acid
Molecular Formula
C7H3ClF3NO2
Molecular Weight
225.55 g/mol
SMILES
c1c(cnc(c1C(=O)O)C(F)(F)F)Cl
InChIKey
SWAUZBSMIIDEMA-UHFFFAOYSA-N
Last Updated: 2026-01-02 00:31
