Compound Q&A
How is 1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine (CAS: 832114-09-7) typically synthesized?
Answer
![1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine](https://static.chemtradehub.com/structs/832/832114-09-7-0ebe.webp "1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine")
1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine is synthesized via the Suzuki coupling reaction, where 1-methyl-4-pyridinylpiperazine is reacted with 4,4,5,5-tetramethyl-2-borono-1,3,2-dioxaborolane in the presence of a palladium catalyst and base. The reaction conditions typically include Pd(PPh3)4 as the catalyst and Na2CO3 as the base. The yield is generally high, and the product is isolated by column chromatography.
About
CAS No
832114-09-7
English Name
1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine
Molecular Formula
C16H26BN3O2
Molecular Weight
303.22 g/mol
SMILES
CN1CCN(CC1)c2cc(ccn2)B3OC(C)(C)C(C)(C)O3
InChIKey
CERIBIOLVVNLDM-UHFFFAOYSA-N
Last Updated: 2026-01-01 15:34
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