1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine(CAS: 832114-09-7)

1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine is a white crystalline solid with a molecular weight of approximately 422.4 g/mol. It has poor water solubility but is soluble in organic solvents like DMSO and DMF. This compound reacts with nucleophiles via its boron atom. It is stable under normal conditions but should be handled with care to avoid decomposition.

1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine is synthesized via the Suzuki coupling reaction, where 1-methyl-4-pyridinylpiperazine is reacted with 4,4,5,5-tetramethyl-2-borono-1,3,2-dioxaborolane in the presence of a palladium catalyst and base. The reaction conditions typically include Pd(PPh3)4 as the catalyst and Na2CO3 as the base. The yield is generally high, and the product is isolated by column chromatography.

1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine is used in the pharmaceutical industry for its potential as a drug candidate. It is also explored in the polymer industry for synthesizing new materials. Additionally, it has applications in sensor technology and semiconductor manufacturing due to its chemical reactivity and structural properties.

When handling 1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperazine, ensure proper personal protective equipment (PPE) usage, including gloves, safety glasses, and a lab coat. Store it in a dry, well-ventilated area and use a fume hood during preparation. Spills should be promptly cleaned up with appropriate absorbent materials. Consult the Safety Data Sheet (SDS) for detailed safety information and emergency response procedures.