How is N,N'-(1R,2R)-1,2-Cyclohexanediylbis[N'-[3,5-bis(trifluoromethyl)phenyl]thiourea] (CAS: 743458-79-9) typically synthesized?

This compound is synthesized via a multi-step process involving the coupling of thiourea derivatives with 1,2-cyclohexanediamine. The reaction is catalyzed by a palladium-based catalyst under mild conditions. The yield is typically around 70-80% and the selectivity is excellent. The synthesis requires careful control of reaction temperature and pressure to ensure product purity.