Compound Q&A
How is 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline (CAS: 1375108-46-5) typically synthesized?
Answer
7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline is usually synthesized via a palladium-catalyzed coupling reaction. Specifically, quinazoline and a boronic acid ester are reacted in the presence of a palladium catalyst, such as Pd(PPh3)4, under a nitrogen atmosphere. The reaction typically achieves a yield of over 80% with excellent regioselectivity.
About
CAS No
1375108-46-5
English Name
7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline
Molecular Formula
C14H17BN2O2
Molecular Weight
256.11400000000003 g/mol
SMILES
B1(OC(C(O1)(C)C)(C)C)C2=CC3=NC=NC=C3C=C2
InChIKey
RJXJTNJULNSBLM-UHFFFAOYSA-N
Last Updated: 2025-12-25 22:28
