Compound Q&A
How is 2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine (CAS: 80681-25-0) typically synthesized?
Answer
2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine is typically synthesized via a multi-step process involving the isobutyrylation of guanosine-2'-phosphate followed by deprotection and fluorination. Commonly used solvents include dichloromethane and acetonitrile. The synthesis involves the use of isobutyryl chloride and hydrogen fluoride as reagents. Yield and selectivity are generally high, with a yield of about 70-80%.
About
CAS No
80681-25-0
English Name
2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine
Molecular Formula
C14H18FN5O5
Molecular Weight
355.33 g/mol
SMILES
OC[C@@H]1[C@H]([C@@H](F)[C@H](N2C=NC3=C2N=C(NC(C(C)C)=O)NC3=O)O1)O
InChIKey
SLHADUUWJSVYGQ-HTFXMJNNSA-N
Last Updated: 2025-11-08 00:00
