2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine(CAS: 80681-25-0)

2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine (CAS: 80681-25-0) is a nucleoside derivative. It is a white or off-white crystalline solid with a high molecular weight of approximately 486.2 g/mol. The compound is poorly soluble in water and organic solvents. It exhibits limited reactivity under normal conditions but may undergo hydrolysis in basic solutions. The compound has good stability under acidic conditions.

2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine is typically synthesized via a multi-step process involving the isobutyrylation of guanosine-2'-phosphate followed by deprotection and fluorination. Commonly used solvents include dichloromethane and acetonitrile. The synthesis involves the use of isobutyryl chloride and hydrogen fluoride as reagents. Yield and selectivity are generally high, with a yield of about 70-80%.

2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine (CAS: 80681-25-0) is primarily used in the pharmaceutical industry for its potential as an anticancer drug candidate. It is also of interest in the development of nucleic acid-based therapies. Additionally, it may have applications in sensor technology and as a research tool in molecular biology.

When handling 2'-Deoxy-2'-fluoro-N2-isobutyrylguanosine (CAS: 80681-25-0), ensure the use of Personal Protective Equipment (PPE) including gloves, lab coat, and safety goggles. Handle in a well-ventilated area or a fume hood to avoid inhalation. Avoid skin contact and ingestion. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.