Compound Q&A
How is (2-Cyclopropylpyrimidin-5-yl)boronic acid (CAS: 893567-15-2) typically synthesized?
Answer
(2-Cyclopropylpyrimidin-5-yl)boronic acid can be synthesized through the coupling of 2-cyclopropylpyrimidine-5-boronic acid pinacol ester with a suitable boronic ester in the presence of a palladium catalyst and a base. Commonly, tris(dibenzylideneacetone)dipalladium(0) and tri-ortho-tolylphosphine are used as catalysts, and potassium carbonate or sodium carbonate as the base. The reaction typically shows high selectivity and yield.
About
CAS No
893567-15-2
English Name
(2-Cyclopropylpyrimidin-5-yl)boronic acid
Molecular Formula
C7H9BN2O2
Molecular Weight
163.97 g/mol
SMILES
B(C1=CN=C(N=C1)C2CC2)(O)O
InChIKey
HIBBMEFTPMTWOY-UHFFFAOYSA-N
Last Updated: 2025-11-07 12:11
