(2-Cyclopropylpyrimidin-5-yl)boronic acid(CAS: 893567-15-2)

(2-Cyclopropylpyrimidin-5-yl)boronic acid has a crystalline form and a molecular weight of approximately 249.23 g/mol. It has a low solubility in water but is more soluble in organic solvents. The compound is moderately reactive, particularly in boron-halide and boron-nitrogen bond reactions. It exhibits good stability under normal conditions but should be stored away from strong oxidizing agents.

(2-Cyclopropylpyrimidin-5-yl)boronic acid can be synthesized through the coupling of 2-cyclopropylpyrimidine-5-boronic acid pinacol ester with a suitable boronic ester in the presence of a palladium catalyst and a base. Commonly, tris(dibenzylideneacetone)dipalladium(0) and tri-ortho-tolylphosphine are used as catalysts, and potassium carbonate or sodium carbonate as the base. The reaction typically shows high selectivity and yield.

(2-Cyclopropylpyrimidin-5-yl)boronic acid is primarily used in the pharmaceutical industry, where it serves as a building block for organic synthesis. It is also utilized in the development of sensors and semiconductors due to its unique chemical and physical properties.

When handling (2-Cyclopropylpyrimidin-5-yl)boronic acid, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a dry, cool place away from strong oxidizing agents. In case of a spill, use appropriate spill cleanup materials and consult the Safety Data Sheet (SDS) for detailed instructions. The fume hood should be used during handling to minimize exposure to volatile compounds.