Compound Q&A
How is 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole (CAS: 882562-40-5) typically synthesized?
Answer
3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole is commonly synthesized through a multi-step reaction involving the condensation of 2,5-dichloropyrimidine with phenylsulfonyl isocyanate, followed by amination. Various catalysts such as triethylamine and catalytic amounts of HOBt can be used to improve the yield and selectivity. This compound is often used as a key intermediate in the development of new pharmaceuticals.
About
CAS No
882562-40-5
English Name
3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole
Molecular Formula
C18H11Cl2N3O2S
Molecular Weight
404.28 g/mol
SMILES
C1=CC=C(C=C1)S(=O)(=O)N2C=C(C3=CC=CC=C32)C4=NC(=NC=C4Cl)Cl
InChIKey
ZSDGZYGEBQECGY-UHFFFAOYSA-N
Last Updated: 2025-11-04 22:31
