Compound Q&A
How is Ethyl 4-bromo-2-(trifluoromethoxy)benzoate (CAS: 933785-18-3) typically synthesized?
Answer
Ethyl 4-bromo-2-(trifluoromethoxy)benzoate (CAS: 933785-18-3) is commonly synthesized via a Friedel-Crafts reaction using 2-(trifluoromethoxy)benzoic acid and bromine in the presence of a Lewis acid catalyst like aluminum trichloride. The reaction is highly selective and yields a high percentage of the desired product. Proper handling of bromine and Lewis acids is essential to ensure a safe and efficient synthesis process.
About
CAS No
933785-18-3
English Name
Ethyl 4-bromo-2-(trifluoromethoxy)benzoate
Molecular Formula
C10H8BrF3O3
Molecular Weight
299.04 g/mol
SMILES
COC(=O)c1ccc(Br)cc1OC(F)(F)F
InChIKey
QDAATKCEXCYIPG-UHFFFAOYSA-N
Last Updated: 2025-11-04 22:31
