Compound Q&A
How is Diethyl 3-hydroxy-1,1-cyclobutanedicarboxylate (CAS: 99974-66-0) typically synthesized?
Answer
Diethyl 3-hydroxy-1,1-cyclobutanedicarboxylate can be synthesized via the condensation of 3-hydroxy-1,1-cyclobutanedicarboxylic acid with diethyl malonate in the presence of a base like sodium hydride. The reaction is typically carried out in anhydrous dimethylformamide (DMF) at room temperature. The yield is usually around 85%, and the reaction is highly selective, producing a pure diester product.
About
CAS No
99974-66-0
English Name
Diethyl 3-hydroxy-1,1-cyclobutanedicarboxylate
Molecular Formula
C10H16O5
Molecular Weight
216.23 g/mol
SMILES
CCOC(=O)C1(CC(C1)O)C(=O)OCC
InChIKey
HCVGFHCQRXXAGH-UHFFFAOYSA-N
Last Updated: 2025-11-04 13:04
