Compound Q&A
How is 2-Chloro-1H-indole-3-carbaldehyde (CAS: 5059-30-3) typically synthesized?
Answer
2-Chloro-1H-indole-3-carbaldehyde (CAS: 5059-30-3) is typically synthesized through a condensation reaction between indole and chloral hydrate in the presence of a base like sodium hydroxide. The reaction is carried out in an organic solvent such as ethanol. The yield is usually around 70-80%, with high selectivity for the desired product. The reaction is known to be mild and can be optimized using various conditions to improve yield and purity.
About
CAS No
5059-30-3
English Name
2-Chloro-1H-indole-3-carbaldehyde
Molecular Formula
C9H6ClNO
Molecular Weight
179.61 g/mol
SMILES
C1=CC=C2C(=C1)C(=C(N2)Cl)C=O
InChIKey
XYSSNBNFOBVMAU-UHFFFAOYSA-N
Last Updated: 2025-10-31 20:53
