2-Chloro-1H-indole-3-carbaldehyde(CAS: 5059-30-3)

2-Chloro-1H-indole-3-carbaldehyde (CAS: 5059-30-3) is a white to off-white crystalline solid with a molecular weight of approximately 201.6 g/mol. It has a low water solubility and is soluble in organic solvents like methanol and ethanol. This compound is known for its aromatic character and is relatively stable under normal conditions but can react with reducing agents. It is polar and has a significant dipole moment.

2-Chloro-1H-indole-3-carbaldehyde (CAS: 5059-30-3) is typically synthesized through a condensation reaction between indole and chloral hydrate in the presence of a base like sodium hydroxide. The reaction is carried out in an organic solvent such as ethanol. The yield is usually around 70-80%, with high selectivity for the desired product. The reaction is known to be mild and can be optimized using various conditions to improve yield and purity.

2-Chloro-1H-indole-3-carbaldehyde (CAS: 5059-30-3) is primarily used in the pharmaceutical industry for the synthesis of biologically active compounds. It is also utilized in the chemical industry for the development of new materials and in the sensor industry for the production of gas sensors. Additionally, it has potential applications in the semiconductors industry for manufacturing electronic components.

When handling 2-Chloro-1H-indole-3-carbaldehyde (CAS: 5059-30-3), it is important to use personal protective equipment (PPE) such as gloves, safety goggles, and a laboratory coat. This compound should be stored in a cool, dry place away from heat and direct sunlight. It should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, neutralize the spill with an appropriate cleaning agent and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.