How is 5-(Methoxymethyl)-1,3,4-thiadiazol-2-amine (CAS: 15884-86-3) typically synthesized?

5-(Methoxymethyl)-1,3,4-thiadiazol-2-amine is usually synthesized by the reaction of 5-chloromethoxymethyl-1,3,4-thiadiazol-2-amine with an amine. This process involves the substitution of the chlorine atom with the amino group, catalyzed by a base such as potassium hydroxide. The yield is generally around 85%, and the reaction is carried out in an aprotic solvent like dimethylformamide.