Compound Q&A

How is 3-(Trifluoromethyl)benzenecarboximidamide hydrochloride (CAS: 62980-03-4) typically synthesized?

Answer

3-(Trifluoromethyl)benzenecarboximidamide hydrochloride (1:1)
3-(Trifluoromethyl)benzenecarboximidamide hydrochloride is typically synthesized via the reaction of 3-(trifluoromethyl)benzoyl chloride with ammonia followed by hydrochloric acid treatment. The reaction is usually conducted in the presence of a catalyst to improve yield and selectivity. Common conditions include refluxing the reaction mixture in a suitable solvent such as benzene or toluene.

About

CAS No 62980-03-4
English Name 3-(Trifluoromethyl)benzenecarboximidamide hydrochloride (1:1)
Molecular Formula C8H8ClF3N2
Molecular Weight 224.61299999999994 g/mol
SMILES NC(=N)c1cccc(c1)C(F)(F)F.Cl
InChIKey JRWQLKZLTWPEBO-UHFFFAOYSA-N
Last Updated: 2025-10-29 13:16

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