How is (1R,3S,5R)-2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-azabicyclo[3.1.0]hexane-3-carboxylic acid (CAS: 197142-34-0) typically synthesized?

This compound can be synthesized via a multi-step process including the formation of a cyclic amide and subsequent protection of the amine. Commonly, a protected amine is reacted with an acyl chloride in the presence of a base to form the cyclic ester. The specific conditions, such as the choice of catalysts (e.g., DMAP, HOBt), solvents, and temperatures, can vary depending on the method used. The overall yield is typically around 70-80%.