Compound Q&A
How is the GLP-1 moiety from Dulaglutide (CAS: 923950-08-7) typically synthesized?
Answer
The GLP-1 moiety from Dulaglutide (CAS: 923950-08-7) is typically synthesized through solid-phase peptide synthesis (SPPS) using Fmoc chemistry. Commonly, the process involves stepwise assembly of protected amino acids on a solid support, followed by cleavage with strong acids like trifluoroacetic acid (TFA). The final product is then purified by reverse-phase HPLC, ensuring high purity and yield. The synthesis process requires careful control of pH and temperature to maintain optimal reactivity and selectivity.
About
CAS No
923950-08-7
English Name
GLP-1 moiety from Dulaglutide
Molecular Formula
C19H15N3O3
Molecular Weight
333.35 g/mol
SMILES
CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NCC(=O)NCC(=O)NCC(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CC6=CNC=N6)N
InChIKey
UENSIXLPLYMXMK-UHFFFAOYSA-N
Last Updated: 2025-10-23 07:31
