Compound Q&A
How is [4-(Trifluoromethoxy)phenoxy]acetic acid (CAS: 72220-50-9) typically synthesized?
Answer
![[4-(Trifluoromethoxy)phenoxy]acetic acid](https://static.chemtradehub.com/structs/722/72220-50-9-70f4.webp "[4-(Trifluoromethoxy)phenoxy]acetic acid")
[4-(Trifluoromethoxy)phenoxy]acetic acid can be synthesized by the condensation of 4-(trifluoromethoxy)phenol with acetic anhydride in the presence of a catalytic amount of sulfuric acid. The reaction is typically carried out at room temperature and involves the formation of an ester through an acylation process. The product is purified by recrystallization from ethanol or a suitable solvent.
About
CAS No
72220-50-9
English Name
[4-(Trifluoromethoxy)phenoxy]acetic acid
Molecular Formula
C9H7F3O4
Molecular Weight
236.14 g/mol
SMILES
C1=CC(=CC=C1OCC(=O)O)OC(F)(F)F
InChIKey
QHSBEEUEIRDHCD-UHFFFAOYSA-N
Last Updated: 2025-10-22 12:37
![[4-(Trifluoromethoxy)phenoxy]acetic acid — HePeng （ ShangHai ） Biotechnology Co Ltd](https://static.chemtradehub.com/suppliers/67ceccf22b2de6e8e95a5e0f/67ceccf22b2de6e8e95a5e0f-logo.webp){kind=logo}
![[4-(Trifluoromethoxy)phenoxy]acetic acid — Jin Jinle (Hunan) Chemical Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce76192b2de6e8e95a464e/67ce76192b2de6e8e95a464e-logo.webp){kind=logo}