Compound Q&A
How is 1,5-Dichloro-2-nitro-4-(trifluoromethyl)benzene (CAS: 400-70-4) typically synthesized?
Answer
1,5-Dichloro-2-nitro-4-(trifluoromethyl)benzene is typically synthesized via the Friedel-Crafts alkylation of 2-nitro-4-(trifluoromethyl)benzene with chlorine, followed by nitration. The reaction is usually carried out under anhydrous conditions with a Lewis acid catalyst such as aluminum chloride (AlCl3). The yield is moderate, around 50-70%, depending on the purity and handling of reactants.
About
CAS No
400-70-4
English Name
1,5-Dichloro-2-nitro-4-(trifluoromethyl)benzene
Molecular Formula
C7H2Cl2F3NO2
Molecular Weight
259.99 g/mol
SMILES
C1=C(C(=CC(=C1[N+](=O)[O-])Cl)Cl)C(F)(F)F
InChIKey
VLVNHMVSVDVAOA-UHFFFAOYSA-N
Last Updated: 2025-10-22 12:37
