Compound Q&A
How is 6-Chloro-1H-indazole-3-carboxylic acid (CAS: 129295-31-4) typically synthesized?
Answer
6-Chloro-1H-indazole-3-carboxylic acid can be synthesized by the condensation of 3-chloroindazole with carboxylic anhydride, followed by hydrolysis. Another method involves the reaction of indazole with chloroacetyl chloride in the presence of a base. The yield is typically around 75-85%, and the use of a suitable catalyst can improve selectivity and yield.
About
CAS No
129295-31-4
English Name
6-Chloro-1H-indazole-3-carboxylic acid
Molecular Formula
C8H5ClN2O2
Molecular Weight
196.59 g/mol
SMILES
C1=CC2=C(C=C1Cl)NN=C2C(=O)O
InChIKey
MCGHMISXTKQRRF-UHFFFAOYSA-N
Last Updated: 2025-10-20 00:35
