Compound Q&A
How is 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine (CAS: 81279-39-2) typically synthesized?
Answer
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine is typically synthesized through a multi-step process involving coupling of guanosine with DMT (N,N'-Diisopropylcarbodiimide) and Boc (tert-butoxycarbonyl) protecting groups. The synthesis involves protecting the hydroxyl groups and then installing the desired functionalities, followed by deprotection to obtain the final product. This process requires careful selection of reagents and conditions to achieve high yield and selectivity.
About
CAS No
81279-39-2
English Name
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine
Molecular Formula
C41H51N5O8Si
Molecular Weight
769.97 g/mol
SMILES
CC(C)C(NC(N1)=NC2=C(N=CN2[C@@H]3O[C@H](COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6)[C@@H](O)[C@H]3O[Si](C)(C(C)(C)C)C)C1=O)=O
InChIKey
JMCNKJFOIJGYRG-CJEGOSRCSA-N
Last Updated: 2025-10-20 00:35
