Compound Q&A
How is 1-[4-(4-Propionyl-1-piperazinyl)-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-2(1H)-one (CAS: 1222998-36-8) typically synthesized?
Answer
![1-[4-(4-Propionyl-1-piperazinyl)-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-2(1H)-one](https://static.chemtradehub.com/structs/122/1222998-36-8-23cb.webp "1-[4-(4-Propionyl-1-piperazinyl)-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-2(1H)-one")
This compound is typically synthesized through a multi-step process involving condensation reactions and electrophilic aromatic substitution. Common synthetic methods include using 4-(4-propionyl-1-piperazinyl)-3-(trifluoromethyl)benzoic acid and 3-quinolinyl hydrazine as starting materials, with appropriate catalysts and reagents. The yield is generally around 60-70%, with good selectivity to the desired product.
About
CAS No
1222998-36-8
English Name
1-[4-(4-Propionyl-1-piperazinyl)-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-2(1H)-one
Molecular Formula
C35H28F3N5O2
Molecular Weight
607.64 g/mol
SMILES
CCC(=O)N1CCN(CC1)c1ccc(cc1C(F)(F)F)n1c(=O)ccc2c1c1cc(ccc1nc2)c1cnc2c(c1)cccc2
InChIKey
AKCRNFFTGXBONI-UHFFFAOYSA-N
Last Updated: 2025-10-20 00:35
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