Compound Q&A
How is 2-Fluoro-5-(trifluoromethoxy)benzoic acid (CAS: 886497-85-4) typically synthesized?
Answer
2-Fluoro-5-(trifluoromethoxy)benzoic acid can be synthesized through a Fries rearrangement of 5-(trifluoromethoxy)benzyl trifluoromethanesulfonate with fluoroacetic anhydride. The process involves the use of a Lewis acid catalyst, such as aluminum trichloride, to promote the rearrangement. The yield is typically around 60-70%, and the method is selective for the desired product.
About
CAS No
886497-85-4
English Name
2-Fluoro-5-(trifluoromethoxy)benzoic acid
Molecular Formula
C8H4F4O3
Molecular Weight
224.10899999999995 g/mol
SMILES
C1=CC(=C(C=C1OC(F)(F)F)C(=O)O)F
InChIKey
CSMVUVGPLMTFIZ-UHFFFAOYSA-N
Last Updated: 2025-10-17 07:35
