Compound Q&A
How is [4-(Benzyloxy)-3-chlorophenyl]boronic acid (CAS: 845551-44-2) typically synthesized?
Answer
![[4-(Benzyloxy)-3-chlorophenyl]boronic acid](https://static.chemtradehub.com/structs/845/845551-44-2-acad.webp "[4-(Benzyloxy)-3-chlorophenyl]boronic acid")
[4-(Benzyloxy)-3-chlorophenyl]boronic acid is typically synthesized via a multistep process starting from 3-chlorophenol. The key steps include benzyl protection, chlorination, and subsequent formation of the boronic acid via a boronation reaction. Commonly used catalysts include Pd(PPh3)4 and Na2CO3. The overall yield is around 60-70%.
About
CAS No
845551-44-2
English Name
[4-(Benzyloxy)-3-chlorophenyl]boronic acid
Molecular Formula
C13H12BClO3
Molecular Weight
262.501 g/mol
SMILES
Clc1cc(ccc1OCc1ccccc1)B(O)O
InChIKey
AYSMMNDQVZAXQY-UHFFFAOYSA-N
Last Updated: 2025-10-17 07:35
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