Compound Q&A
How is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-D-histidine (CAS: 135610-90-1) typically synthesized?
Answer
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This compound is synthesized using fluorenylmethoxycarbonyl (Fmoc) chemistry. The Fmoc-protected histidine is coupled to a trityl-protected amino acid or peptide via standard peptide coupling reactions. Typical conditions involve the use of HATU or DCC as coupling agents, and diisopropylethylamine as a base. The product is purified by flash chromatography or reversed-phase HPLC.
About
CAS No
135610-90-1
English Name
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-D-histidine
Molecular Formula
C40H33N3O4
Molecular Weight
619.72 g/mol
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)CC(C(=O)O)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57
InChIKey
XXMYDXUIZKNHDT-DIPNUNPCSA-N
Last Updated: 2025-10-10 21:10
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