Compound Q&A
How is 5-(Trifluoromethyl)-2(1H)-pyridinethione (CAS: 76041-72-0) typically synthesized?
Answer
5-(Trifluoromethyl)-2(1H)-pyridinethione can be synthesized by the reaction of 2-(trifluoromethyl)pyridine with hydrogen sulfide at elevated temperatures. The reaction is typically carried out in the presence of a base such as potassium carbonate to enhance the nucleophilicity of the sulfur donor. The yield is generally good, and the product can be isolated by recrystallization from appropriate solvents.
About
CAS No
76041-72-0
English Name
5-(Trifluoromethyl)-2(1H)-pyridinethione
Molecular Formula
C6H4F3NS
Molecular Weight
179.17 g/mol
SMILES
C1=CC(=S)NC=C1C(F)(F)F
InChIKey
YFSCXLSUZZXNHW-UHFFFAOYSA-N
Last Updated: 2025-10-05 08:54