Compound Q&A

How is 2-Chloro-5-fluorobenzaldehyde (CAS: 84194-30-9) typically synthesized?

Answer

2-Chloro-5-fluorobenzaldehyde
2-Chloro-5-fluorobenzaldehyde (CAS: 84194-30-9) can be synthesized by the reaction of 5-fluorobenzaldehyde with chlorine gas in the presence of a Lewis acid catalyst such as aluminum chloride. The yield is typically around 70-80%, and the reaction is highly selective for the chlorination position. Other methods include direct chlorination of 5-fluorobenzene in an acidic medium.

About

CAS No 84194-30-9
English Name 2-Chloro-5-fluorobenzaldehyde
Molecular Formula C7H4ClFO
Molecular Weight 158.56 g/mol
SMILES Fc1ccc(Cl)c(C=O)c1
InChIKey SOEFVBXUNROUOX-UHFFFAOYSA-N
Last Updated: 2025-09-29 09:43

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