Compound Q&A

How is 1-Bromo-4-ethoxy-2,3-difluorobenzene (CAS: 156573-09-0) typically synthesized?

Answer

1-Bromo-4-ethoxy-2,3-difluorobenzene
1-Bromo-4-ethoxy-2,3-difluorobenzene (CAS: 156573-09-0) is typically synthesized through the reaction of 2,3-difluorobenzoic acid with a mixture of bromine and ethyl bromide. The process involves bromination followed by ethoxylation. Optimal conditions include the use of a catalytic amount of a Lewis acid such as aluminum chloride to enhance the reaction rate and yield. The product is isolated by recrystallization from appropriate solvents.

About

English Name 1-Bromo-4-ethoxy-2,3-difluorobenzene
Molecular Formula C8H7BrF2O
Molecular Weight 237.04 g/mol
SMILES CCOC1=C(C(=C(C=C1)Br)F)F
InChIKey OJZVBJOHBGYINN-UHFFFAOYSA-N
Last Updated: 2025-09-29 09:43

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