Compound Q&A
How is (2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide (CAS: 257933-82-7) typically synthesized?
Answer
![(2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide](https://static.chemtradehub.com/structs/257/257933-82-7-0be2.webp "(2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide")
This compound is typically synthesized via a multi-step route involving the condensation of a 3-cyano-7-ethoxy-6-quinolinone derivative with a 4-aminophenylamine containing a 3-chloro-4-fluorophenyl group, followed by a series of alkylation and amidation reactions. The synthesis involves the use of standard reagents and catalysts under mild to moderate conditions, with good selectivity and yield.
About
CAS No
257933-82-7
English Name
(2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide
Molecular Formula
C24H23ClFN5O2
Molecular Weight
456.95 g/mol
SMILES
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C
InChIKey
WVUNYSQLFKLYNI-AATRIKPKSA-N
Last Updated: 2025-09-28 13:06
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