Compound Q&A
How is 6-(Trifluoromethyl)nicotinic acid (CAS: 231291-22-8) typically synthesized?
Answer
6-(Trifluoromethyl)nicotinic acid can be synthesized by the trifluoromethylation of nicotinic acid. This reaction typically involves treating nicotinic acid with trifluoromethyl triflate in the presence of a base like sodium hydride or potassium tert-butoxide. The process yields a high purity product with a yield of up to 75-80%. Additional purification steps such as recrystallization from methanol or ethanol may be required to achieve the desired crystalline form.
About
CAS No
231291-22-8
English Name
6-(Trifluoromethyl)nicotinic acid
Molecular Formula
C7H4F3NO2
Molecular Weight
191.11 g/mol
SMILES
C1=CC(=NC=C1C(=O)O)C(F)(F)F
InChIKey
JNYLMODTPLSLIF-UHFFFAOYSA-N
Last Updated: 2025-09-26 00:09
