Compound Q&A
How is Tipifarnib (CAS: 192185-72-1) typically synthesized?
Answer
Tipifarnib is synthesized via a multi-step process involving condensation, alkylation, and functional group transformations. Key steps include the synthesis of a piperidine ring and subsequent alkylation at the C20 position of farnesyl pyrophosphate. The reaction typically uses organic solvents and catalysts like palladium, with high selectivity and yield around 80-90%.
About
CAS No
192185-72-1
English Name
Tipifarnib
Molecular Formula
C27H22Cl2N4O
Molecular Weight
489.41 g/mol
SMILES
CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
InChIKey
PLHJCIYEEKOWNM-HHHXNRCGSA-N
Last Updated: 2025-09-26 00:09